General Health

Manufacturing Water-Soluble Vitamins with BL Bio Lab

Manufacturing Water-Soluble Vitamins with BL Bio Lab

The process of manufacturing water-soluble vitamins is no easy task, however, with the right supplement company, the process is extremely efficient. While there are many different ways to go about the process, every company must start somewhere.

Difference Between Water-Soluble & Fat-Soluble

The normal human body, whether it is a male or female, young or old, requires a multitude of nutrients to survive. In order to function properly, the body must have vitamins and minerals in its system at all times. There are two kinds of vitamins: fat-soluble and water-soluble.

Vitamins can be found in many different kinds of foods, although certain types of food are rich in specific vitamins. For example, leafy greens are full of vitamin A while oranges provide a lot of Vitamin C. Vitamins that are fat-soluble can be stored in the body for long periods of time whereas water-soluble vitamins are not easily stored in the body and have to be replenished on a regular basis.

Manufacturing Water-Soluble Vitamins with BL Bio LabWater-Soluble Vitamins & the Human Body

Water-soluble vitamins (B and C) cannot be stored in their natural forms in the body, because they dissolve easily in water. These vitamins must constantly be replenished from foods containing them. This makes these vitamins more susceptible to disease-causing deficiencies than any other group of nutrients. Because of this danger, the knowledge necessary for the efficient production of water-soluble vitamin supplements has been developed over several decades by supplement manufacturers. In addition, efficient methods have been developed for purifying water-soluble vitamins from plant sources—fruits and vegetables—and microbial fermentation processes have been engineered to produce large quantities of B-vitamin complex at low costs. There are a few drawbacks associated with these processes that limit the stability and efficacy of the final product.

Water-soluble vitamins are organic substances or elements that have to be in soluble form, are not stored by the body, and need to be ingested every day through food intake. There are four major water-soluble vitamins: B1, B2, B6, and C. These vitamins dissolve easily in water so they cannot be stored for long periods in their natural forms in the body. Due to this reason, these vitamins can become deficient quickly when certain procedures halt their absorption into the digestive system. Because these deficiencies arise quickly, it is extremely important that sufficient amounts of water-soluble vitamins are consumed daily to avoid serious medical problems occurring later down the line. The biggest risk with deficient levels of water-soluble vitamins is the development of neural tube defects. The causes for this deficiency can be restricted intake of certain foods, loss or destruction of the vitamins in the food we eat (over-cooking and processing), increased water loss from vegetables through cooking, and alcohol consumption which results in a decline of absorption by the body.

Microbial Fermentation Process

The production process for these supplements starts with biomass material which can come from plant sources such as fruits and vegetables or microbial fermentation processes. The production process extracts out the required vitamin complexes either through chemical extraction methods or more recently using bioreactor systems. Bioreactor systems are advantageous because they produce higher yields of products thus saving money on expenses such as labor and energy costs. The limitation with this system is that it is not very efficient, requiring an increase in the concentration of biomass material to yield higher levels of productivity. Chemical extraction methods are advantageous because they can be used to produce both water-soluble vitamins C and B complex, but chemical reactions required to extract each vitamin vary by compound so it becomes difficult to control the equilibrium involved during processing.

Manufacturing Water-Soluble Vitamins with BL Bio LabChemical Extraction for Water-Soluble Vitamins

Chemical extraction of water-soluble vitamins should use food-grade solvents that would not interfere with the final product or impact food safety. There are four main physical or chemical steps that go into chemical extraction: flocculation, precipitation, filtration, and washing. Flocculation involves mixing the biomass with a chemical solvent which causes large particles within the mixture to attach together forming what is referred to as a floc. Precipitation involves mixing the biomass and floc to form a solution with small particles within it called slurry, this slurry is then heated up causing precipitation which results in the chemical solvent being pushed away from the newly formed precipitate. Filtration removes solids that remain after the separation of water-soluble vitamins from biomass material by washing them off with either distilled or demineralized water. Lastly, the final step involves drying out both crystals and dampness to achieve a reasonable purity level for storage purposes until they are ready for packaging and distribution.

Water-soluble vitamins can be produced in various ways but two main methods exist hydrolysis and microbial fermentation. During hydrolysis plant sources such as fruits and vegetables are chopped up and exposed to either hot water or organic solvents to extract different vitamins. The extracts from this process undergo further steps such as deionization, concentration, distillation, crystallization, and drying which can be quite expensive leading to increased costs of products. Microbial fermentation is a much more cost-effective method because it only requires the use of microbial cultures instead of chopping up plant sources and exposure to harsh chemicals and solvents. During this process microbes produce enzymes that break down the carbohydrates into fermentable sugars that will then be fermented into vitamin supplements. Enzymes involved in this process include amylase for starch breakdown, cellulase for cellulose breakdown, xylanase for hemicellulose breakdowns as well as pectinase for a breakdown of pectic compounds.

Manufacturing Water-Soluble Vitamins with BL Bio LabMicrobial fermentation can be carried out using either bacteria or fungi, but the current industry standard is to use bacteria because of cost-effectiveness in comparison to fungi. Using bacteria is advantageous because they produce enzymes that are desired in lower quantities compared to fungi, however, they tend to produce unwanted byproducts which must then undergo extensive purification steps before they can be used in the final product.

There are different types of water-soluble vitamins that can be roughly classified into two groups. They are all essential nutrients for our bodies working together with macrominerals and microminerals in order to maintain normal metabolic processes within the body. Formerly known as vitamin B complex because they are all derived from the B vitamin complex, they include thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7/H/S), and cobalamin (B12). They act as coenzymes within our bodies because their role is to help break down carbohydrates into glucose which acts as the body’s main source of energy.

There are six water-soluble vitamins that can be found in natural food sources, but only five can be produced through chemical extraction.

Fat-soluble vitamins consist of four vitamins A, D, E, and K which are all stored within adipose tissue and liver which is why they are known as liposoluble vitamins. Unlike water-soluble vitamins, these ones need fat in order to properly mix with the body and work. Vitamins A, D, E, and K can all be found in egg yolk, fish oil, butter/lard/margarine, and liver/kidney while fruits and vegetables are the main sources of vitamin C. Note: only vitamin D can be produced by humans through exposure to sunlight, and it is actually a hormone rather than a vitamin.

Manufacturing Water-Soluble Vitamins with BL Bio LabWorking with BL Bio Lab as your Supplement Manufacturer

Today, global companies are constantly looking for partners that can help them to create new products and/or improve old ones. One company that has been rated extremely high in this field is BL Bio Lab. Not only have they managed to stay on top of the market for supplement trends, but they also offer one of the most affordable services on the market today. Although their prices are low, the quality of their work is far from being low-grade, quality is always considered first.

Supplement manufacturing is not an easy process and companies need to go through plenty of research before they can even think about starting production. The next step is then to find a supplement manufacturer and hire them for the job. While many companies will be willing to take your money and produce your product, this may not always be advisable as you could end up with lower-quality products that do not meet the standards you set out.

Many people who are less experienced in the industry may be tempted to buy a private label stock supplement that everyone else is selling, but this is not always the best course of action.

Instead, it would be better to buy a custom-made supplement that will set up apart from your competition. BL Bio Lab has an in-house R&D team that helps with this task.

If you are interested in producing water-soluble supplements or any custom formulation make sure to reach out today.

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